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KMID : 0438219760130030319
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Korea University Medical Journal
1976 Volume.13 No. 3 p.319 ~ p.331
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The Influence of Reserpine and Chlorpromazine on the Histopathological Changes of the Upper Respiratory Mucosa and Lung
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李基性/Lee, Ki Sung
申洪秀/Shin, Hong Soo
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Abstract
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Reserpine and chlorpromazine are the well-known tranquilizers. These preparations are widely used for anti-hypertensive, sedative or diuretic effects.
Many a worker, on the other hand, has presented the considerable side effects of these preparations in the various organs when these drugs are taken over a long period. We, otolaryngologists, are frequently consulted, by many patients who have received these preparations over long periods, for dryness of nasal cavity and/or frequent nasal bleeding.
In this paper the experiment was carried out in order to determine whether these drugs could induce the histopathological change in the respiratory nasal mucosa. In addition, histopathological examination of tracheal mucosa and lung was also carried out for the same purpose.
Male mature rats, weighing 300^400 gm, were used. The animals were divided into 3 groups as follows:
1) Control group
2) Reserpine treated group
3) Chlorpromazine treated group
The control group was given no treatment and lettered as N group in this paper. The reserpine treated group was divided into 2 subgroups: one, treated with reserpine of 1 mg/kg body weight daily for 5 days and lettered as R6 group in this paper; the other, 0.5 mg/kg body weight daily for 20 days and as %,, group in this paper. The chlorpromazine treated group was also divided into 2 subgroups: one, treated with chlorpromazine of 15mg/kg body weight daily for 5 days and lettered as Cr, group in this paper; the other, 7.5 mg/kg body weigt daily for 20 days and as C20 group in
this paper. The substance was in all cases administered as a single daily injection, subcutaneously. The animal was sacrified the day after the last day of treatment. Paraffin sections were made and H-E stain and PAS-Alcian blue pH 2.5 stain were used.
The results obtained w@re´ as follows:
1) The reserpine treated group and the chlorpromazine treated group showed diminished activity of secretory cells, compared with the N group. This result was predominant in the nasal respiratory mucosa, especially in the septa.
2) In the reserpine treated group, the reaction of secretory cells to PAS-Alcian blue pH 2.5 stain diminished in R, group than in Rzo group. In the chlorpromazine treated group, on the other hand, no apparent difference was observed between C. group and Czo group.
3) The reaction of secretory cells to PAS-Alcian blue pH 2.5 stain had a tendency to diminish in the chlorpromazine treated group than in the reserpine treated group.
In the above-mentioned results, the diminished reaction of secretory cells to PAS-Alcian blue pH 2.5 stain was shown to suggest diminished activity of secretory cells, leading to dryness of nasal chamber and frequent nasal bleeding.
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